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Additional Codes

Mayo Code: ALS

Epic Code: LAB556

Interface Order Alias: 10078

Former Cerner Code: 8067


Performing Laboratory

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Mayo Clinic Laboratories in Rochester

Specimen Required

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

CollectionInstructions:

1. Centrifuge within 1 hour of collection and aliquot serum intoplastic vial.

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2. Send refrigerated.


Laboratory Test Directory Note:

COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.


Forms

If not ordering electronically, complete, print, and send aGeneral Request (T239) with the specimen.


Specimen Stability Information

Specimen TypeTemperatureTimeSpecial Container
Serum RedRefrigerated (preferred)7 days
 Frozen 60 days

Clinical Information

Aldolase is necessary for glycolysis in muscle as a "rapidresponse" pathway for production of adenosine triphosphate,independent of tissue oxygen.

 

Aldolase catalyzes the conversion of fructose 1,6-diphosphateinto dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, animportant reaction in the glycolytic breakdown of glucose tolactate in muscle.

 

Aldolase is a tetramer whose primary structure depends upon thetissue from which it was synthesized (highest expression in liver,muscle, brain).

 

Elevated values are found in muscle diseases, such as Duchennemuscular dystrophy, dermatomyositis, polymyositis, and limb-girdledystrophy. While elevated creatinine kinase (CK) levels are moresensitive and specific for muscle disease, occasionally elevatedaldolase is observed in some patients with myositis that havenormal CK values.

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Reference Values

Test IDTest Order NameOrder LOINC ValueALSAldolase, S1761-6

 

Result IDTest Result NameResult LOINC Value
ALSAldolase, S1761-6



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